Heterologous transplantation of cancer of childhood.

The high degree of anaplasia and the early metastatic dissemination observed in many cancers of childhood suggest considerable autonomy of the neoplastic tissue, and readiness to transgress species barriers, as demonstrated by successful transfer into the anterior chamber of the guinea pig's eye. During the past two years many of the malignant neoplasms submitted to the Department of Pathology of The Children's Hospital, Boston, were inoculated into the anterior chamber of the guinea pig's eye following the technic described by Greene (1). A total of 2 7 tumors were inoculated into 158 guinea pigs. The number of animals inoculated ranged from I to 20 (Table I) . Most of these